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Iyar herbals- herbals and supplements

Curcumin
herbs for cancer

Turmeric and Curcumin has been shown to have a wide spectrum of biological actions.
Its anticancer effect is mainly mediated through induction of apoptosis.

 Clinically, curcumin has already been used to reduce post-operative inflammation.
Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at
 very high dose without any toxic effects.

Thus, both turmeric and curcumin have the potential for the development of modern medicine for the treatment of various diseases.

Turmeric for cancer

Curcumin and anticancer activity:

 

One form of curcumin's activity is preventing the action of the nuclear factor

NF-KAPPAB. When this factor is activated,  it affects abnormal inflammatory activity

which leads to various pathological conditions, such as arthritis and cancer. In addition, there are who Argue that to this factor there is an impact on the formation of symptoms who are related to Cancer, such as loss of appetite, weight loss, fatigue, depression, anxiety, Neuropathic pain and other conditions.(1)

 

 

There are who attribute some of the anti-cancer activity of curcumin as a direct action

of   the active blocking of NF-KAPPAB. 

The production blocking of this factor returns part of the Cancer cells to "normal". Furthermore this block also prevents a Metastasis. (2)

Curcumin for cancer

Curcumin's activity was tested extensively in in-vitro studies (laboratory testing)
showed a number of activities:

 

* Preventing activation of specific genes that cause cancer (Genes for NF-κB, STAT3, COX2).

* Prevention of tumor cell from multiplying.

* Prevent the transformation of normal cells to cancer cells.

* Destruction of cells that have become cancer cells.

* Prevent the spread of tumors to other organs.

* Prevent the development of the necessary blood supply to the cancer cell development

 

 

These activities demonstrated against most of the known types of cancer, such as breast cancer, Prostate cancer, lung cancer, colon cancer, and more. (3)

 

Turmeric and Curcumin health studies:

  1. Role of nuclear factor-κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents Subash C Gupta,1 Ji Hye Kim,1 Ramaswamy Kannappan,1 Simone Reuter,1 Patrick M Dougherty,2 and Bharat B Aggarwal1

  2. Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res. 2014 Mar 19. Epub ahead of print.

  3. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins Ajaikumar B. Kunnumakkara, Preetha Anand, Bharat B. Aggarwal

    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA Published Online: May 14, 2008

  4. Indian J Pharmacol. 2015 Mar-Apr;47(2):160-6. doi: 10.4103/0253-7613.153422. Exploring the role of curcumin containing ethanolic extract obtained from Curcuma longa (rhizomes) against retardation of wound healing process by aspirin. Pawar RS1, Toppo FA1, Mandloi AS1, Shaikh S1.

  5. J Mol Cell Cardiol. 2015 Feb;79:1-12. doi: 10.1016/j.yjmcc.2014.10.002. Epub 2014 Oct 16. Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo.

  6. Harefuah. 2015 Jan;154(1):56-8, 66. Curcumin add-on therapy for ulcerative colitis.

  7. Otol Neurotol. 2014 Jun;35(5):e169-77. Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.Fetoni AR1, Eramo SL, Paciello F, Rolesi R, Podda MV, Troiani D, Paludetti G.

  8. Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001, 21, 2895–2900.

  9. Ricky A. Sharma, Stephanie A. Euden, et al.  Phase I Clinical Trial of Oral Curcumin  Biomarkers of Systemic Activity and Compliance . Clinical Cancer Research  2004, 10, 6847-6854

  10. 2011 Nov;14(6):588-97. Curcuma as a functional food in the control

  11.  of cancer and inflammation.Schaffer M1, Schaffer PM, Zidan J, Bar Sela G

All written in this site, including health benefit statements has not been evaluated by the united states Food and Drug Administration. These products which are presented in this web site, are not intended to diagnose, treat, cure, or prevent any disease. Iyar herbals ltd. read more about this

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